Maria Almeida

This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.

TENGU improves spatial transcriptomics by using transcript-signal density for cell segmentation and simulation, enhancing accuracy in complex tissues.

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.

This study shows estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts, reducing bone resorption through suppression of SIRT3 activity.

This study creates a harmonized atlas of murine bone-associated cells using single-cell RNA sequencing to clarify cell type designations and identify osteoblast progenitors.