Endosulfan rewires GSK3β to disrupt primary cilia-dependent Hedgehog signalling
Ravikant Piyush, Himani Barmola, Anwesha Bhattacharjya, Abhinn Gupta, Prasenjit Bhaumik, Sathees C. Raghavan, Bibha Choudhary, Sudarshan Gadadhar, Satyanarayan Rao, Swapnil Rohidas Shinde
This study shows endosulfan disrupts Hedgehog signaling by altering GSK3β activity, leading to ciliopathy-like effects in mice and linking to human reproductive disorders.
bioRxiv · Sep 30, 2026 · PreprintCell Biology