Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer
Dimitra P. Anastasiadou, Nicole Couturier, Sakshi Goel, Dimitrios G Argyris, Stepan Vodopyanov, Luis Rivera Sanchez, Edgar Gonzalez, Jesse Kreger, Anthony J. Griffen, Abigail Kazakov, Joseph Burt, Natasha Recoder, Camille L. Duran, Allison S. Harney, Agathe Quesnel, , George S. Karagiannis
This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.
bioRxiv · Oct 15, 2024 · PreprintCancer Biology