Edgar Gonzalez

A class act: HDAC1-Malat1 regulates MDSC apoptosis and cell cycling to decrease suppression of T cells

The paper shows HDAC1 inhibition in MDSCs increases Malat1, decreases pSTAT3, induces apoptosis and cell cycle arrest, and reduces T cell suppression.

Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune suppressive parameters in metastatic breast cancer

The paper develops mathematical models and Bayesian inference methods to analyze tumor-immune dynamics in metastatic breast cancer, revealing immune suppressive parameters as key predictors of response to immunotherapy.

Cancer systems immunology reveals myeloid - T cell interactions and B cell activation mediate response to checkpoint inhibition in metastatic breast cancer

The paper investigates how myeloid-T cell interactions and B cell activation influence response to checkpoint inhibition in metastatic breast cancer using multi-omics and computational methods.

Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.