George S. Karagiannis

This study identifies macrophage Tie2 signaling as critical for TMEM doorway-mediated vascular permeability and metastatic dissemination in breast cancer.

This paper introduces a digital pathology pipeline to analyze thymic structure and function, demonstrating its application in a mouse model of age-related thymic involution.

This paper combines MALDI-MSI and LC-MS/MS to map spatial protein changes in murine thymus during chemotherapy, identifying key proteins involved in regeneration and immune recovery.

This study shows paclitaxel induces MenaINV in breast cancer cells by repolarizing tumor-associated macrophages, enhancing metastasis.

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

The paper characterizes a novel syngeneic murine breast cancer model (NT2.5-LM) that exhibits rapid and widespread metastases, enabling study of metastatic progression and therapeutic responses.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.