SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function
Emma S Winkler, Adam L Bailey, Natasha M Kafai, Sharmila Nair, Broc T McCune, Jinsheng Yu, Julie M Fox, Rita E Chen, James T Earnest, Shamus P Keeler, Jon H Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, , Michael S Diamond
This study shows that SARS-CoV-2 infection in K18-hACE2 mice causes severe lung inflammation, immune cell infiltration, and respiratory dysfunction similar to human COVID-19.
bioRxiv · Jul 9, 2020 · PreprintImmunology