Author

Richard Head

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Yidan SuniD· 3 shared Yuqing WuiD· 2 shared Adam L Bailey· 1 shared Annette Robichaud· 1 shared Broc T McCune· 1 shared Catrina C. FronickiD· 1 shared Christopher Markovic· 1 shared Cody Peng· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersGenomics

Yidan SunORCID

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Author profile →

4 papers

Recent·Most cited

High-order enhancer hubs buffer allelic regulatory variation through kinetic compensation

Jiang Tan, Monica F. Sentmanat, Yukiv Wu, Cody Peng, Catrina C. Fronick, Christopher Markovic, Xiaoxia Cui, R J Fulton, Richard Head, Ting Wang, Yidan Sun

The paper develops Nanopore-HiChIP to map enhancer hubs and shows they buffer allelic regulatory variation through kinetic compensation, preserving balanced transcriptional output.

bioRxiv · Sep 21, 2026 · PreprintGenomics

SnakeHichipTF reveals transcription factor logic underlying enhancer-promoter wiring in the human brain

Jiang Tan, Yuqing Wu, Richard Head, Yidan Sun

SnakeHichipTF decodes TF logic in enhancer-promoter wiring in human brain regions, revealing distinct regulatory programs and evolutionary elements.

bioRxiv · Apr 1, 2026 · PreprintGenomics

SnakeAltPromoter Facilitates Differential Alternative Promoter Analysis

Jiang Tan, Yuqing Wu, Ruteja A. Barve, Jared M. Lalmansingh, Fuhai Li, Philip Payne, Nahyun Kong, Sheng Chih Jin, Yuqi Shan, Ruiwen Zhou, Xinzhou Ge, Jingyi Jessica Li, Richard Head, Yidan Sun

SnakeAltPromoter provides a reproducible framework for differential alternative promoter analysis using RNA-seq, benchmarked against CAGE data and scalable for large datasets.

Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBioinformatics

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

Emma S Winkler, Adam L Bailey, Natasha M Kafai, Sharmila Nair, Broc T McCune, Jinsheng Yu, Julie M Fox, Rita E Chen, James T Earnest, Shamus P Keeler, Jon H Ritter, Liang-I Kang, Sarah Dort, Annette Robichaud, Richard Head, , Michael S Diamond

This study shows that SARS-CoV-2 infection in K18-hACE2 mice causes severe lung inflammation, immune cell infiltration, and respiratory dysfunction similar to human COVID-19.

bioRxiv · Jul 9, 2020 · PreprintImmunology