M. Ding

Systematic and proactive evaluation of AIRE missense variant effects

This study proactively evaluates the functional effects of 9790 AIRE missense variants using a reporter assay, providing evidence for 70% of previously classified variants of uncertain significance.

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Landscapes of missense variant impact for human superoxide dismutase 1

The paper measures the functional impact of over two thousand SOD1 missense variants using saturation mutagenesis and cell-based assays, reclassifying 41% of previously uncertain variants as pathogenic.

Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease

This study identifies MRTF as a key mediator of fibrosis in PKD by showing its activation following PC1/2 loss and its role in epithelial fibrogenesis.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

An ancient transcription activator is required for the multiciliogenesis program

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stability

This study shows IL-16 promotes atherosclerotic plaque stability by upregulating TIMP-3 through STAT6 and CBP/p300 recruitment.

Pathogen Clearance-based Correlates of Immunoprotection Reveal Insightful Features of Vaccine Immunity

This paper introduces a new vaccine evaluation system based on pathogen clearance and liver trapping to assess immunoprotective potential against bacterial infections.

Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

Regulation of mRNA transcripts, protein isoforms, glycosylation and spatial localization of ACE2 and other SARS-CoV-2-associated molecules in human airway epithelium upon viral infection and type 2 inflammation

This study examines how viral infection and type 2 inflammation affect ACE2 and related proteins in human airway epithelium, showing differential regulation of mRNA and protein expression.

Long non coding RNA L13Rik promotes high glucose-induced mesangial cell injury by regulating miR-2861/CDKN1B axis

This study identifies L13Rik as a lncRNA that promotes mesangial cell injury in diabetic nephropathy by regulating the miR-2861/CDKN1B axis.

The cyclin Cln1 controls polyploid titan cell formation following a stress-induced G2 arrest in Cryptococcus

This study identifies Cln1 as a regulator of G2 arrest and titan cell formation in Cryptococcus neoformans under stress conditions.

Chemoproteomics Maps Glycolytic Targetome in Cancer Cells

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

Intracellular accumulation and secretion of hydrophobin-enriched vesicles aid the rapid sporulation of molds

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in human tissues and immune cells in health and disease

The paper examines the expression of SARS-CoV-2-related molecules in human tissues and immune cells across health and disease states, identifying age, comorbidities, and immune cell types associated with altered expression.

Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig

This study develops a recombinant ACE2-Ig fusion protein that neutralizes both SARS-CoV and 2019-nCoV in vitro, showing cross-reactivity and potential for diagnostic, prophylactic, and therapeutic applications.

TIGIT-Fc Promote Immune Tolerance at the Feto-maternal Interface

The paper shows TIGIT-Fc promotes immune tolerance at the feto-maternal interface by enhancing IL-10 production and TH2 polarization in decidual CD4+ T cells, and increasing pregnancy rates in stressed mice.

High-fidelity continuum modeling predicts avian voiced sound production

The paper develops and validates a high-fidelity 3D continuum model for avian voiced sound production, showing it accurately predicts vibratory and acoustic traits.

Jasmonate-regulated ERF109-MYB51-MYC3 ternary complexes control indolic glucosinolates biosynthesis

The paper identifies the ERF109-MYB51-MYC3 ternary complex as a regulator of jasmonate-induced indolic glucosinolate biosynthesis.

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

Treatment of Murine Lupus with TIGIT-Ig

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

CTCF-mediated Chromatin Structures Dictate the Spatio-temporal Propagation of Replication Foci

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

Targeting RyR2 with a phosphorylation site-specific nanobody Reverses Dysfunction of Failing Cardiomyocytes in Rat

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.