Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia
Maria Ibrahim, Maria Gomez-Jenkins, Adina Scheinfeld, Zhengqiao Zhao, Eduardo Cararo Lopes, Akshada Sawant, Zhixian Hu, Aditya Dharani, Michael Sun, Sarah Siddiqui, Emily T. Mirek, Johan Abram-Saliba, Edmund C. Lattime, Xiaoyang Su, Tobias Janowitz, , Eileen White
This paper shows autophagy prevents cachexia by suppressing CCL2, which damages appetite-promoting neurons, leading to lethal weight loss in mice.
bioRxiv · Feb 20, 2025 · PreprintMolecular Biology