Xiaoyang Su

This paper identifies IMPDH as a therapeutic target in PTEN-deficient T-ALL, showing IMPDH inhibitors selectively kill these cells and extend survival in mouse models.

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

The paper identifies SLC45A4 as a peroxisomal putrescine transporter that enhances GABA de novo synthesis via the AOP pathway.

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

This study shows that bioenergetic stress from antibiotic treatment enhances antimicrobial resistance and persistence in E. coli through increased ROS, repair mechanisms, and stringent response activation.

This paper shows autophagy prevents cachexia by suppressing CCL2, which damages appetite-promoting neurons, leading to lethal weight loss in mice.

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.

The paper identifies microbially-produced phospholipids that reduce inflammation and counteract antibiotic-induced type 1 diabetes in mice, with similar effects observed in humans.

This study shows coral larvae maintain carbon provisioning from algal symbionts under heat stress by sequestering nitrogen into dipeptides, reducing symbiont growth but preserving photosynthesis and carbon transfer.

The paper identifies phosphatidic acid and its analogues as lipid regulators that selectively inhibit PIEZO2 channels, revealing the PLD pathway's role in modulating PIEZO2 activity and mechanical sensitivity.

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

This study characterizes the thermal stress response in Montipora capitata using transcriptomic and metabolomic data, revealing key gene and metabolite changes associated with stress.