Author

Ailin Han

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Amin H. NassariD· 2 shared Esen SefikiD· 2 shared Holly N. BlackburniD· 2 shared J. Richard Brewer· 2 shared Richard Anthony FlavelliD· 2 shared Tianli XiaoiD· 2 shared Alexander L Gusev· 1 shared Athreya S RangavajhulaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Amin H. NassarORCID

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3 papers

Recent·Most cited

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

Tianli Xiao, J. Richard Brewer, Maximillian J. Carlino, Ailin Han, Yamato J. Takabe, Chia‐Yi Lee, Fengrui Zhang, Mi Chen, Holly N. Blackburn, Amin H. Nassar, Qiankun Wang, Kristen Brennand, Liang Shan, Esen Sefik, Diane S. Krause, Richard Anthony Flavell

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

Journal of Clinical Investigation · Sep 14, 2026Peer-reviewedImmunology

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

J. Richard Brewer, Ailin Han, Amin H. Nassar, Elias Bou Farhat, Holly N. Blackburn, Tianli Xiao, Haris Mirza, Walter K. Mowel, Esen Sefik, Saskia Hartner, Michael Chiorazzi, Takeshi Ito, Min Hee Oh, Matthew Z. Madden, Athreya S Rangavajhula, , Richard Anthony Flavell

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

bioRxiv · Jul 3, 2026 · PreprintImmunology

Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue

Yubao Cheng, Shengyuan Dang, Yuan Zhang, Yanbo Chen, Ruihuan Yu, Liu Miao, Shengyan Jin, Ailin Han, Samuel G. Katz, Siyuan S. Wang

This paper introduces RAEFISH, a spatial transcriptomics technology that achieves whole-genome coverage and single-molecule resolution in intact tissues, enabling comprehensive analysis of RNA localization and cell interactions.

bioRxiv · Mar 6, 2025 · PreprintGenetics