Microglia-derived IL-18 remodels hippocampal plasticity to constrain traumatic fear memory
xiya fang, yining wang, yezhuang shen, Guanbo Xie, Ran Liu, Hong Cai, Qiuying Han, Xin Xu, Kai Wang, Libing Yin, Jinwei Di, Tao Zhou, Ailing Li, Xiao Han, Weihua Li, Teng Li
This study shows that microglia-derived IL-18 reduces traumatic fear memory by restoring synaptic plasticity and modulating engram cell organization in the hippocampus.
bioRxiv · May 7, 2026 · PreprintNeuroscience