Xin Xu

Lamin A/C coordinates nuclear mechanics, chromatin architecture, and transcriptional homeostasis in skeletal muscle in vivo

This study investigates how Lamin A/C disruption affects nuclear mechanics, chromatin architecture, and transcription in skeletal muscle in vivo, finding that it alters chromatin organization and gene expression in mechanically stiff tissues.

Patient-specific "Physical Twin" artery-on-chip platform reveals complex flow-dependent VWF mechanobiology and guides personalized antithrombotic therapy

The paper develops a patient-specific artery-on-chip platform to study flow-dependent VWF mechanobiology and guide personalized antithrombotic therapy.

Microglia-derived IL-18 remodels hippocampal plasticity to constrain traumatic fear memory

This study shows that microglia-derived IL-18 reduces traumatic fear memory by restoring synaptic plasticity and modulating engram cell organization in the hippocampus.

Specification of the interstitial cell lineage in the fetal mouse ovary requires balanced Notch signaling

The paper identifies Notch signaling as critical for specifying the interstitial lineage in fetal mouse ovaries through single-nucleus transcriptomics and lineage tracing.

Identification of distinct functions of GLIS3 in β-cell generation critical to prevention of neonatal diabetes

This study identifies two distinct roles of GLIS3 in β-cell development, showing its critical function in bipotent progenitor generation and preβ-to-β cell differentiation, contributing to neonatal diabetes in GLIS3-deficient mice.

Single-nucleus multiomics of murine gonadal cells reveals transcriptional regulatory network underlying supporting lineage differentiation

The paper identifies a transcriptional regulatory network in murine gonadal supporting cells that underlies sex differentiation, revealing how chromatin changes and gene expression drive Sertoli and granulosa cell fates.

Squash ensures Spindle-E-dependent heterotypic ping-pong amplification of piRNAs in the Drosophila ovary

This study identifies Squash as a cofactor of Spindle-E that ensures heterotypic ping-pong piRNA amplification in Drosophila ovaries, preventing transposable element de-repression.

Exploring the Neural Basis and Validity of Ordinal Emotion Representation through EEG

This study investigates the neural basis and validity of ordinal emotion representation using EEG data, showing it better captures emotional experiences than interval scales.

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.