Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology
Szi Kay Leung, Emma Walker, Stefania S S Policicchio, Aisha Dahir, Dorothea Seiler Vellame, Adam R. Smith, Rhian Swarbrick, Katie Lunnon, Emma Louise Dempster, Zeshan Ahmed, Eilis J. Hannon, Isabel Castanho, Jonathan S. Mill
The paper identifies DNA methylation changes in transgenic mouse models of Alzheimer's disease, showing distinct patterns for tau and amyloid-beta pathology and some overlap with human AD data.
npj Dementia · Apr 7, 2026Peer-reviewedNeuroscience