Alan J. Thomas

The paper uses connectome-based brain fingerprinting to identify early cognitive decline markers in Parkinson's patients with minor hallucinations using resting-state fMRI.

The paper investigates dopaminergic and serotonergic changes in the subgenual cingulate cortex of dementia with Lewy bodies patients with and without depression, finding reduced dopaminergic innervation and markers in depressed cases.

This study shows that intracellular Aβ correlates with AT-8 phosphorylated tau in frontal cortex tissue from non-AD and AD brains, supporting the revised amyloid cascade hypothesis.

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

The paper identifies DNA methylation signatures in Alzheimer's disease cortex, showing most changes are driven by non-neuronal cell types.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

The paper develops a novel DNA methylation clock optimized for human cortex tissue, outperforming existing clocks and highlighting issues with previous associations between DNA methylation age and neurodegenerative phenotypes.

This study examines dynamic functional connectivity in dementia with Lewy bodies and Alzheimer’s disease, finding reduced network efficiency variability in DLB but no significant clinical correlations.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

The paper compares brain network efficiency in Lewy body dementia, Alzheimer’s disease, and healthy controls using EEG data, finding reduced connectivity and compensatory responses in certain frequency bands.