Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure
Di Lang, Haibo Ni, Roman Y. Medvedev, F. V. Liu, Claudia P. Alvarez-Baron, Leonid Tyan, Daniel G. P. Turner, Aleah Warden, Stefano Morotti, Thomas A. Schrauth, Baron Chanda, Timothy J. Kamp, Gail A. Robertson, Eleonora Grandi, Alexey V. Glukhov
This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.
JACC. Clinical electrophysiology · Feb 19, 2026Peer-reviewedPhysiology