Sustained antigenic engagement programs multidimensional CTL states with distinct cytotoxic capacities
Hazyadee Frecia Rodríguez-Gutiérrez, Ashwin Jainarayanan, Marie Tosolini, Fereshteh Aslani, Anne-Laure Iscache, Sabina Müller, Béatrice Corre, Alejandro Vanazzi, Mirudula Elanchezhian, Camille Laurent, Salvatore Valitutti, Roxana Khazen
This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.
bioRxiv · Oct 18, 2026 · PreprintImmunology