Roxana Khazen

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

This study shows that human CTLs sustain cytotoxicity by selectively replenishing granzyme B through de novo synthesis, maintaining its activity and supporting prolonged killing.

This study shows that Polo-like kinase 1 (PLK1) is essential for immune synapse (IS) assembly and cytotoxic T cell function by regulating microtubule dynamics during IS formation.