Author

Alex Watterson

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Emre KarakoçiD· 2 shared Gabriele PiccoiD· 2 shared Mathew J. GarnettiD· 2 shared Matthew A. CoelhoiD· 2 shared Barbara Abreu· 1 shared Benoît BaillifiD· 1 shared Cansu DinçeriD· 1 shared Chiara Maria CattaneoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Emre KarakoçORCID

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2 papers

Recent·Most cited

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Katrina McCarten, Barbara Abreu, Benoît Baillif, Lisa Koob, Jong Sook Ahn, Cansu Dinçer, Julian Esselborn, Emre Karakoç, R. Frederick Ludlow, John F. Lyons, Gabriele Picco, Mamta Sharma, Marcel L. Verdonk, Mark R. Wade, Samantha J. Walker, , Mathew J. Garnett

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

bioRxiv · Sep 14, 2026 · PreprintGenomics

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

Alex Watterson, Gabriele Picco, Vivien Veninga, Youhani Samarakoon, Chiara Maria Cattaneo, Sara F. Vieira, Emre Karakoç, Shriram G. Bhosle, Thomas Battaglia, Sarah Consonni, Timotheus Y.F. Halim, Emile E. Voest, Mathew J. Garnett, Matthew A. Coelho

The paper identifies CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance through CRISPR screens and shows their potential as biomarkers for immunotherapy response.

Cell Reports Medicine · Jan 1, 2026Peer-reviewedCancer Biology