Antigen-dependent activation of marginal zone B cells amplifies hypertension
Hericka Bruna Figueiredo Galvão, Maria Jelinic, Maggie Lieu, Vivian Tran, Buddhila Wickramasinghe, Jake N. Robertson, Tayla A. Gibson Hughes, Henry Diep, Asha Haslem, Mathew G. Lewsey, Alexander Bobik, Christopher Graeme Sobey, Tomasz Jan Guzik, Grant Raymond Drummond, Antony Vinh
This study identifies marginal zone B cells as antigen-responsive subsets that amplify immune responses in hypertension through clonal expansion and intercellular communication with CD8+ T cells.
bioRxiv · Oct 17, 2025 · PreprintPhysiology