Genetic and Pharmacologic Targeting of Eya3 in Macrophages Drives Anti-Tumor Immunity in Triple-Negative Breast Cancer
Kaiah M. Fields, Gabriela Terue Rizzo Kodama, Etienne P. Danis, Jessica G. Olivas-Corral, Sheera R. Rosenbaum, Uma Kantheti, Goksu Sarioglu, Erin Citarella, Lars Wick, Kate Matlin, Brooke Aloe, Emmy G. Hawkins, Arthur R. Wolin, Alexander LaVeck, Connor J. Hughes, , Heide L. Ford
This study identifies Eya3 in macrophages as a checkpoint for anti-tumor immunity in TNBC, showing that its depletion or inhibition enhances immune responses and reduces tumor growth.
bioRxiv · Oct 22, 2026 · PreprintCancer Biology