Yang Zhang

Myogenic and neural transcriptional circuitry determines PAX3::FOXO1 driven initiation of rhabdomyosarcoma

This study uses a PAX3::FOXO1 inducible model to show P3F initiates ARMS transformation but is not required for maintaining proliferation or transcriptional programs.

Growth rate structures the dynamics of bacterial trait evolution

This study shows growth rate is a major organizing axis shaping bacterial trait evolution across timescales, with distinct slow- and fast-growing regimes and varying coupling with other traits.

Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

The paper identifies a core regulatory circuit in rhabdomyosarcoma and shows that targeting two co-activators synergistically inhibits tumor growth.

Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infection

The paper screens bile salt analogs to identify compounds that reduce lipid accumulation in liver cells and inhibit C. difficile spore germination, offering potential dual therapy for MASLD and CDI.

In vivo measurement and prediction of cell-type-resolved non-coding variant effects in human immunity

The paper measures and predicts non-coding variant effects in human immune cells using single-cell ATAC-seq and whole-genome sequencing, revealing regulatory mechanisms and applications in systemic lupus erythematosus.

A Lightweight Dual-Attention Neural Network for In-Situ Hyperspectral Classification of Microalgae

This paper introduces a lightweight dual-attention neural network for real-time hyperspectral classification of microalgae, achieving 98.91% accuracy on a custom dataset.

Cannabidiol Inhibits PIEZO Channels to Mitigate Red Blood Disorders

This paper shows that cannabidiol inhibits PIEZO channels in red blood cells, reducing calcium overload and related pathologies in hereditary xerocytosis and sickle cell disease.

Timing the onset of homologous recombination deficiency before breast cancer diagnosis

The paper estimates the timing of homologous recombination deficiency (HRD) onset in breast cancers using HRDTimer, finding HRD occurs years before diagnosis in different subtypes.

Sludge liquefaction and stratification enable ultra-high digestion rate and resource recovery for waste activated sludge treatment

The paper introduces a novel sludge treatment process called SPREAD that significantly improves organic loading rates and nutrient recovery in waste activated sludge treatment.