Author

Alexander Pichugin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander Ivanov· 2 shared Bidisha Bhattacharya· 2 shared Bo-Shiun Yan· 2 shared Igor KramnikiD· 2 shared John Connor· 2 shared Lester KobzikiD· 2 shared Robert Berland· 2 shared Yuanwei Gao· 2 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexander Ivanov

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Author profile →

2 papers

Recent·Most cited

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

Bidisha Bhattacharya, Shiqi Xiao, Sujoy Chatterjee, Michael Urbanowski, Alvaro Ordonez, Elizabeth A Ihms, Garima Agrahari, Shichun Lun, Robert Berland, Alexander Pichugin, Yuanwei Gao, John Connor, Alexander Ivanov, Bo-Shiun Yan, Lester Kobzik, , Igor Kramnik

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.

bioRxiv · Dec 19, 2018 · PreprintImmunology

Increased susceptibility to intracellular bacteria and necrotic inflammation driven by a dysregulated macrophage response to TNF

Bidisha Bhattacharya, Sujoy Chattrerjee, Robert Berland, Alexander Pichugin, Yuanwei Gao, John Connor, Alexander Ivanov, Bo-Shiun Yan, Lester Kobzik, Igor Kramnik

The paper identifies a dysregulated macrophage response to TNF in sst1-deficient mice, leading to increased susceptibility to intracellular bacteria and necrotic inflammation.

bioRxiv · Mar 15, 2018 · PreprintImmunology