Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.
Alexander Walker, Paula Olaizola, Euan Brennan, Edward J. Jarman, Yuelin Yao, Elizabeth Carmichael, Andreea Grãdinaru, Alexander E.P. Loftus, David H. Wilson, Anabel Martinez Lyons, Laura Charlton, Kimberley Ober, Wunan Mi, Amy Broeders, Kyle Davies, , Luke Boulter
This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.
bioRxiv · Apr 21, 2025 · PreprintCell Biology