Author

Alfonso Brenlla

University of St Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1

Frequent Co-Authors

Paolo AnnibaleiD· 2 shared Andrew Morton· 1 shared Annette Gabriele Beck‐SickingeriD· 1 shared Gunnar KleinauiD· 1 shared Heike BiebermanniD· 1 shared Iqra SohailiD· 1 shared Javier Ananda TelloiD· 1 shared Laila Deen· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Paolo AnnibaleORCID

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2 papers

Recent·Most cited

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

Iqra Sohail, Suli‐Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Üretmen Kagıalı, Marie‐José Blouin, Javier Ananda Tello, Annette Gabriele Beck‐Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter James McCormick, Paolo Annibale, Heike Biebermann

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

Nature Communications · Sep 25, 2025Peer-reviewedPharmacology & Toxicology

The ratio between experimental and theoretical localization precision of single molecules is sensor-dependent and typically larger than one

Alfonso Brenlla, Laila Deen, Paolo Annibale

The paper examines the discrepancy between theoretical and experimental localization precision in single-molecule imaging, finding that experimental precision is often higher than theoretical estimates.

Biophysical Reports · Jul 24, 2025Peer-reviewedBiophysics