MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor
Iqra Sohail, Suli‐Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Üretmen Kagıalı, Marie‐José Blouin, Javier Ananda Tello, Annette Gabriele Beck‐Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter James McCormick, Paolo Annibale, Heike Biebermann
This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.
Nature Communications · Sep 25, 2025Peer-reviewedPharmacology & Toxicology