Author

Alina Ostrowska

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Assay:long-read sequencing· 1 Organism:rat· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro Soto–GutiérreziD· 2 shared Anthony Dick HoiD· 1 shared Anton SelichiD· 1 shared Argyris PapantonisiD· 1 shared Axel SchambachiD· 1 shared Bao‐Guo Ren· 1 shared Björn RathiD· 1 shared Bo Ram YangiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPathology

Alejandro Soto–GutiérrezORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

Zhiping Hu, Takeshi Kurihara, Yiyue Sun, Zeliha Cetin, Rodrigo Machado Florentino, Lanuza A. P. Faccioli, Zhenghao Liu, Bo Ram Yang, Alina Ostrowska, Joseph D. Locker, Alejandro Soto–Gutiérrez, Evan R. Delgado

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

Frontiers in Gastroenterology · Nov 12, 2024Peer-reviewedPathology

Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells

Silvia Liu, Yanping Yu, Bao‐Guo Ren, Tuval Ben-Yehezkel, Caroline A. Obert, Mat Smith, Wenjia Wang, Alina Ostrowska, Alejandro Soto–Gutiérrez, Jianhua Luo

The paper uses long-read single-cell sequencing to identify mutation-specific mRNA isoforms and fusion transcripts in liver cancer cells, improving classification of cancer versus benign cells.

eLife · Jun 23, 2023Peer-reviewedGenomics

Epigenetic drift during long-term culture of cells in vitro

Julia Franzen, Theodoros Georgomanolis, Anton Selich, Chao‐Chung Kuo, Reinhard J. Stöger, Lilija Brant, Melita Sara Mulabdić, Eduardo Fernández‐Rebollo, Clara Grezella, Alina Ostrowska, Matthias Begemann, Miloš Nikolić, Björn Rath, Anthony Dick Ho, Michael Rothe, , Wolfgang Wagner

This study identifies DNA methylation changes during long-term cell culture that resemble epigenetic drift, linked to chromatin conformation changes.

Communications Biology · May 19, 2021Peer-reviewedGenomics