Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5
Kala K. Mahen, William J. Massey, Danny Orabi, Amanda L Brown, Thomas C. Jaramillo, Amy C Burrows, Anthony J. Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes, Venkateshwari Varadharajan, Lucas J. Osborn, Xiayan Ye, Dante M Yarbrough, Treg M. Grubb, , Jonathan Mark Brown
This study shows that gut microbe-derived TMA affects circadian rhythms through the host receptor TAAR5, impacting metabolism and behavior in mice.
bioRxiv · Apr 3, 2025Biochemistry