Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles
Orr Shahar, Alexander Botvinnik, Masha Chaykin, Amit Shwartz, Elad Lerer, Peretz Golding, May Ben Ari, Ori Shalev, Tzuri Lifschytz, Bernard Lerer
This study compares the acute pharmacology and long-term neuroplastic effects of DMT and 5-MeO-DMT in mice, showing distinct behavioral and molecular outcomes.
bioRxiv · Aug 12, 2026 · PreprintNeuroscience