Author

Amy Barrett

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Anna L. GloyniD· 3 shared Anne ClarkiD· 2 shared Benoît HastoyiD· 2 shared Carla BurrowsiD· 2 shared Martijn van de BuntiD· 2 shared Patrik RorsmaniD· 2 shared Vibe NylanderiD· 2 shared Amanda J. BennettiD· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenomics

Anna L. GloynORCID

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Author profile →

3 papers

Recent·Most cited

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

Matthias Thurner, Martijn van de Bunt, Jason Torres, Anubha Mahajan, Vibe Nylander, Amanda J. Bennett, Kyle J. Gaulton, Amy Barrett, Carla Burrows, Christopher G. Bell, Robert Lowe, Stephan Beck, Vardhman K. Rakyan, Anna L. Gloyn, Mark I. McCarthy

The paper integrates chromatin accessibility and DNA methylation data from human pancreatic islets to refine regulatory mechanisms at Type 2 Diabetes susceptibility loci.

eLife · Feb 7, 2018Peer-reviewedGenomics

Electrophysiological properties of human β-cell lines EndoC-βH1 and -βH2 conform with human β-cells

Benoît Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita Chibalina, Amy Barrett, Carla Burrows, Andrei Tarasov, Raphael Scharfmann, Anna L. Gloyn, Patrik Rorsman

This study examines the electrophysiological and secretory properties of human β-cell lines EndoC-βH1 and -βH2, finding they closely resemble primary human β-cells in insulin secretion and ion channel behavior.

bioRxiv · Nov 29, 2017 · PreprintCell Biology

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

Anne Raimondo, Søren Krogsgaard Thomsen, Benoît Hastoy, Mahesh Michael Umapathysivam, Xiao-Qing Dai, Jocelyn E. Manning Fox, Amy Barrett, Christopher J. Groves, Austin Bautista, Nicola L. Beer, Anne Clark, Patrick E. MacDonald, Patrik Rorsman, Anna L. Gloyn

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.

bioRxiv · Jul 3, 2017 · PreprintGenetics