Nicola L. Beer

The paper develops a deep learning method for adipocyte phenotyping and finds adipocyte area correlates with BMI but no genome-wide significant genetic associations.

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.