Raphaël Scharfmann

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

The paper shows that chromatin folding is organized by recurrent motifs that are reweighted across cell types and states, revealing a structured framework for chromatin variability.

This study shows glucose induces translational regulation of over 400 mRNAs in human pancreatic beta cells via mTOR and eIF2 pathways, independent of transcriptional changes.

The paper validates EndoC-βH1 as a translational human β cell model using omics and characterizes its secretome, finding it secretes 671 proteins in baseline and 3,278 under stress, with exosome secretion as a major mode.

This study examines the electrophysiological and secretory properties of human β-cell lines EndoC-βH1 and -βH2, finding they closely resemble primary human β-cells in insulin secretion and ion channel behavior.