Andrea Repele

The differentiation of myeloid progenitors is effected by cascading waves of coordinated gene expression that remodel cellular physiology in a characteristic sequence

The paper profiles gene expression during myeloid differentiation at high temporal resolution, revealing cascading waves of gene regulation that remodel cellular physiology in a characteristic sequence.

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation

This study investigates how DNA accessibility and transcription factor occupancy influence enhancer activity during macrophage-neutrophil differentiation, showing that TF binding, not total accessibility, drives enhancer upregulation.

Robust Normalization of Luciferase Reporter Data

The paper introduces a regression-based normalization method for Luciferase reporter data, showing it outperforms ratiometric normalization, especially at low transfection efficiency.

The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages

The paper experimentally tests thermodynamic models to decode the cis-regulatory logic of Cebpa enhancers and silencers in myeloid and red-blood cell lineages, revealing dominant repression mechanisms and redundant regulatory architectures.