Shawn Krueger

This study investigates how DNA accessibility and transcription factor occupancy influence enhancer activity during macrophage-neutrophil differentiation, showing that TF binding, not total accessibility, drives enhancer upregulation.

The paper experimentally tests thermodynamic models to decode the cis-regulatory logic of Cebpa enhancers and silencers in myeloid and red-blood cell lineages, revealing dominant repression mechanisms and redundant regulatory architectures.