C3a receptor signalling in ObRb-expressing neurons promotes leptin resistance and obesity-associated cardiac remodelling
Elias Rawish, Carolin Gragoll, Michael Schneider, Timo Rusack, Katharina Kurz, Violetta Pilorz, Sophia Marie Reiners, Sven Geisler, Janti HajAhmad, Nuria López‐Alcántara, Nada Alnaggar, Andreas Teufel, Mirko Otto, Jorge Duque Escobar, Thomas Stiermaier, , Ingo Eitel
This study identifies C3aR signaling in ObRb-expressing neurons as a pathway contributing to leptin resistance and obesity-related cardiac remodeling, with potential therapeutic implications.
bioRxiv · Oct 7, 2026 · PreprintImmunology