Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells
Amal Alsubaiti, Hanin Alamir, Lan Huynh, Tressan Grant, Abdullah Aljohani, Po Han Chou, Yiwei Shi, Maryam Alismail, Lydia R Mason, Andrew Herman, John S. Bridgeman, Christopher J. Holland, Christoph Wülfing
The paper generates and characterizes primary human cytotoxic T cells with suppressed function in vitro, showing their resemblance to exhausted tumor-infiltrating CTL and identifying factors affecting their effector function.
Immunotherapy Advances · Dec 30, 2024Peer-reviewedImmunology