Tressan Grant

This study investigates how ImmTACs activate suppressed cytotoxic T cells, finding they can induce cytolysis but not IFN-gamma secretion, and enhance CTL polarization and calcium signaling.

The paper generates and characterizes primary human cytotoxic T cells with suppressed function in vitro, showing their resemblance to exhausted tumor-infiltrating CTL and identifying factors affecting their effector function.

This study shows TIM3 inhibits spheroid-suppressed CTL but not active CTL, and its function depends on the context of T cell activation and ligand expression.