Early AAV9-mediated SLC9A6 gene replacement preserves cerebellar structure and motor function in the shaker rat model of Christianson syndrome
Kajal Dahiya, Kaanchana Sekaran, Lingye Hu, Andy Bloomfield, Evan Kapasakis, Sonja Henning-Smith, Lisa G Riley, Mactier Evans, Sarah Haslam, Joseph Katakowski, Daria Nesterovich Anderson, Wendy Gold, Collin J Anderson
This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.
bioRxiv · Nov 6, 2026 · PreprintNeuroscience