Targeting CD73-A2aR-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance
Shruti Bansal, Luis Aparicio, Aparna Krishnan, Chang Liu, Lindsay Caprio, Anna M. Chiarella, Samanta Sarti, Jason Piersant, Chelsea L. Rahiman, Julia An, Patrick McCann, Namita Sen, Brian E. Ragaishis, Fatemeh N. Derakhshan, Bret Taback, , Catherine S. Spina
This study shows that targeting CD73-A2aR adenosine signaling with radiotherapy and checkpoint inhibitors improves tumor control by overcoming radioresistance and enhancing antitumor immunity.
bioRxiv · May 29, 2026 · PreprintCancer Biology