Chang Liu

FeatureMAP enables network-guided interpretation of untargeted metabolomics

FeatureMAP improves interpretation of untargeted metabolomics data by integrating annotation, network refinement, and functional analysis, revealing metabolic patterns in Alzheimer's disease.

Partial sleep deprivation diminishes and uncouples neuronal activity and energy metabolism in the live mouse hippocampus

This study shows that partial sleep deprivation reduces and uncouples neuronal activity and oxygen levels in the mouse hippocampus, with effects persisting after recovery.

Restoring Aquaporin-4 alleviates molecular and motor phenotypes in zQ175 mouse model of Huntington disease

This study shows that restoring aquaporin-4 in a Huntington disease mouse model improves glymphatic function and reduces disease-related molecular and motor phenotypes.

Generation and application of human pluripotent stem cells derived peri-nervoids

This study generates human pluripotent stem cell-derived Schwann cells and neural organoids to create a nerve-like construct, showing improved regeneration in mouse models.

Intravital microscopy and statistical image analysis of early engraftment of haematopoietic stem cells reveal dynamic and evolving cellular behaviours linked to progressive differentiation.

The paper uses intravital microscopy and statistical image analysis to study early HSC engraftment, revealing dynamic cellular behaviors linked to differentiation over time.

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

Physiological fatty acid uptake reveals spatial and systemic constraints on nutrient accessibility in vivo

The paper quantifies physiological fatty acid uptake in vivo and shows that nutrient accessibility differs from uptake capacity, shaped by tissue architecture and systemic constraints.

Telomerase RNA regulates the epigenome primed for human lineage commitment

This study shows TERC regulates chromatin accessibility and epigenomic architecture in hESCs, essential for lineage commitment, independent of telomere length.

Targeting CD73-A2aR-Mediated Adenosine Signaling at the Tumor-Immune Interface Overcomes Radioresistance

This study shows that targeting CD73-A2aR adenosine signaling with radiotherapy and checkpoint inhibitors improves tumor control by overcoming radioresistance and enhancing antitumor immunity.

Cell Type-informed Characterization of Spatial Niches from Spatial Multimodal and Multi-omics Data

SpaNECT is a framework for characterizing cell niches from spatial multimodal and multi-omics data, outperforming existing methods in diverse biological contexts.

Specification of the interstitial cell lineage in the fetal mouse ovary requires balanced Notch signaling

The paper identifies Notch signaling as critical for specifying the interstitial lineage in fetal mouse ovaries through single-nucleus transcriptomics and lineage tracing.

The world's first cloned golden wild yak via interspecific SCNT: 4800m donor origin and 4200m vitrified blastocyst transfer

This paper reports the first successful cloning of a golden wild yak using interspecific somatic cell nuclear transfer under extreme high-altitude conditions.

ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

STEAP4+ neutrophils: a promising circulating biomarker for lung metastasis

The paper identifies STEAP4+ neutrophils as a circulating biomarker for lung metastasis, validated in both human and mouse models.

Functional screening of TCR-like antibodies for targeted cancer immunotherapy

This study develops a functional screening method to identify TCR-like antibodies targeting tumor neoantigens, demonstrating their anti-tumor efficacy in vitro and in vivo.

A Novel CREBBP/p300 Activator, YF2, Enhances Cytotoxic and Immune-Mediated Responses in B-Cell Lymphoma

This paper evaluates YF2, a CREBBP/p300 activator, showing it enhances cytotoxicity and immune responses in B-cell lymphoma by restoring acetylation and altering the immune microenvironment.

Integrating immunophenotypes reveals causal relationship between tuberculosis and lung cancer: Mendelian randomization study

This study uses Mendelian randomization to show tuberculosis causally increases lung cancer risk, with an immune phenotype mediating this effect.

A RIPOR2 in-frame deletion is a frequent and highly penetrant cause of adult-onset hearing loss

The paper identifies an in-frame deletion in RIPOR2 as a frequent and highly penetrant cause of adult-onset hearing loss, with implications for genetic therapy.

State-Switching Probability Reveals Sleep-Related Biological Drives in Drosophila

The paper introduces a method to measure sleep pressure and depth in Drosophila using movement data without disrupting behavior, showing these parameters are independent and influence total sleep.