Luis Aparicio

This study shows that targeting CD73-A2aR adenosine signaling with radiotherapy and checkpoint inhibitors improves tumor control by overcoming radioresistance and enhancing antitumor immunity.

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

Smoother integrates positional information into non-spatial models for spatial omics data, enabling accurate imputation, deconvolution, and dimensionality reduction in simulated and real datasets.

This study creates a single-cell atlas of mouse and human prostate epithelium, identifying conserved progenitor populations and anatomical relationships between species.

This paper identifies a universal pattern in single-cell sequencing data and proposes a method to denoise it by distinguishing biological signals from artifacts.