Estrogen-related receptor signaling counters sarcopenia and preserves exercise fitness in naturally aged mice
Danesh H. Sopariwala, Anna DeBruine, Світлана Полякова, Elina Mosa, Eira Mann, Citu Citu, Zhongming Zhao, Ashok Kumar, Vihang A. Narkar
This study shows that ERRγ activation in aged mice reduces sarcopenia by enhancing mitochondrial function, vascularization, and neuromuscular junctions while preserving exercise capacity.
bioRxiv · Jun 11, 2026 · PreprintPhysiology