Expression of tardigrade intrinsically disordered proteins in C. elegans reveals variable effects on aging and stress
Anna Entin, Daniel Hicks, Elijah A. Roditi, Juri Kim, Aeowynn J. Coakley, Adam J. Hruby, Athena Alcala, Naibedya Dutta, Maxim Averbukh, Shivay Parihar, Rebecca Aviles Barahona, Thomas Jiyoung Lee, Veronica Kuo, Vinaya Sahasrabuddhe, Bharat Vivan Thapa, , Ryo Higuchi‐Sanabria
Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.
bioRxiv · Oct 31, 2026 · PreprintGenetics✦ In-depth digest