Naibedya Dutta

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

This paper identifies Epoxyazadiradione as a compound that improves Parkinson's disease symptoms in mice by enhancing heat shock factor 1 and protein degradation pathways without affecting redox balance.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

This study uses RNA-sequencing to analyze transcriptomic changes in C. elegans under different mitochondrial stressors that activate UPRmt, aiming to determine if specific transcriptomic changes correlate with longevity.

This study compares mitochondrial imaging strategies in C. elegans during aging, evaluating transgenic constructs for mitochondrial morphology analysis.

This study shows that azadiradione enhances protein quality control mechanisms and alleviates Parkinson's disease symptoms in preclinical models.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.