Adam J. Hruby

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

SenoQuant is an AI software for analyzing and predicting senescence markers in tissues, offering spatial quantification across imaging modalities and supporting custom models.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

This study investigates the effects of marine sponge-derived mycothiazole and its acetylated derivative on mitochondrial function and aging using in vitro and in vivo models.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.