Regulation between LRRK2 and PP2A signaling in cellular models of Parkinsons disease
Panagiotis S. Athanasopoulos, Anna Memou, Franz Y. Ho, Ahmed Soliman, Henderikus Pots, Vassiliki Papadopoulou, Felix von Zweydorf, Saiganesh Sriraman, Alexander Marc Thouin, Laurine Vandewynckel, William Sibran, Marie‐Christine Chartier‐Harlin, R. Jeremy Nichols, Elisa Greggio, Jean‐Marc Taymans, , Arjan Kortholt
This study identifies a regulatory feedback loop between LRRK2 and PP2A phosphatases in Parkinson's disease, showing that LRRK2 phosphorylates PP2A to disrupt its function and contribute to neuronal death.
Biochemical Journal · May 14, 2026Peer-reviewedNeuroscience