The circadian gene Dec2 promotes pancreatic cancer dormancy by regulating tumor cell antigen presentation to facilitate immune evasion
Lan Wang, Chris R. Harris, Crissy Dudgeon, Orjola Prela, Juliana Cazarin, Ching-Hua Shih, Christina Davidson, Anthony Casabianca, Subhajyoti De, Wade C. Narrow, Jennifer Becker, Paul M. Grandgenett, Michael Anthony Hollingsworth, Jean L. Grem, Minsoo Kim, , Darren R. Carpizo
This study identifies Dec2 as a circadian gene that promotes pancreatic cancer dormancy by reducing MHC-I antigen presentation, enabling immune evasion.
Developmental Cell · Apr 30, 2026Peer-reviewedCancer Biology