Engineered endosymbionts that modulate primary macrophage function and attenuate tumor growth by shifting the tumor microenvironment
Cody S. Madsen, Ashley V. Makela, Chima V. Maduka, Emily M. Greeson, Anthony Tundo, Evran E. Ural, Satyajit Hari Kulkarni, Ahmed A. Zarea, Matti Kiupel, Maryam Sayadi, Christopher H. Contag
This study develops engineered endosymbionts that modulate macrophage function and reduce tumor growth by altering the tumor microenvironment in a murine model.
ACS Applied Bio Materials · Jun 24, 2025Peer-reviewedSynthetic Biology