Chima V. Maduka

This study develops engineered endosymbionts that modulate macrophage function and reduce tumor growth by altering the tumor microenvironment in a murine model.

This study shows that persistent LPS exposure in macrophages leads to a unique immunometabolic profile with altered oxygen consumption, ATP levels, and glycolysis, distinct from short-term LPS responses.

This paper develops anti-FAP antibody-modified nanoparticles that target cardiac fibrosis in a rat model, reducing talabostat dose by 400,000-fold and reversing fibrosis and dysfunction.

This study investigates how PLA degradation products affect macrophage metabolism and inflammation, showing distinct metabolic responses to amorphous and semi-crystalline PLA.

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.