IFNγ-CXCL9-CXCR3 axis links T cell recruitment to skeletal muscle remodelling in human physical frailty
Vanda Ho, Chenshi Lin, Arnab Ray, Hui San Chin, Wei Siong Ong, Heng Boon Low, Dorcas MH Chia, Bhuvaneshwari D O Shunmuganathan, Chung Hwee Thiam, Paul Edward Hutchinson, Frederick HX Koh, MAGNET group, Sylvie Alonso, Shifeng Xue, Arne N. Akbar, , Paul A. MacAry
This paper identifies an IFNγ-CXCL9-CXCR3 axis linking T cell recruitment to skeletal muscle remodelling in human physical frailty, showing its association with fibrosis and potential therapeutic targets.
bioRxiv · Oct 28, 2026 · PreprintImmunology